Cannot sync between local and remote folders

In trying to set up synchronization between local and remote folders, I get the following error in the log:

13] Tue 01Jul14 10:53:59 - (Action: Synchronize domain.com to C:\backup) - Action failed (Last Error Message: Unable to synchronize folders: Could not retrieve additional information about the local path. Please make sure the path exists and the local user has permissions within the folder.).

I don't understand why as administrator is granted read/write perms across the board. Please advise, thank you.